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Literature summary extracted from

  • Sun, Y.; Kucej, M.; Fan, H.Y.; Yu, H.; Sun, Q.Y.; Zou, H.
    Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner (2009), Cell, 137, 123-132.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.49 chromosome
-
 Homo sapiens 5694
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.49 cohesin + H2O Homo sapiens cohesin cleavage by human separase requires DNA in a sequence-nonspecific manner ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.49 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.22.49 all bonds known to be hydrolysed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by an hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage cohesin cleavage by human separase requires DNA in a sequence-nonspecific manner (in vitro). Autocleavage of separase is not stimulated by DNA. Cleavage of the chromosome-associated cohesins is sensitive to nuclease treatment. Homo sapiens
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.49 cohesin + H2O cohesin cleavage by human separase requires DNA in a sequence-nonspecific manner Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.49 separase
-
 Homo sapiens